Last update
4/5/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 23 Researches
8
USERS' SCORE
Good
Based on 18 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Proprietary Probiotic Blend
134 mg (1 Billion CFU§)
†
Lactobacillus rhamnosus (GR-1®)
Lactobacillus reuteri (RC-14®)
Top Medical Research Studies
9
We explored the potential of Lactobacillus strain LC-STH-13 in treating systemic lupus erythematosus (SLE), a challenging autoimmune disorder. Using female MRL/lpr mice prone to lupus, we found that LC-STH-13 significantly lowered anti-autoantibodies and optimized the balance of immune cells.
Additionally, it reduced kidney inflammation by targeting the TLR9/NF-κB signaling pathway and improved gut health. These results are promising, suggesting that LC-STH-13 could be a safe and effective treatment avenue for SLE.
Additionally, it reduced kidney inflammation by targeting the TLR9/NF-κB signaling pathway and improved gut health. These results are promising, suggesting that LC-STH-13 could be a safe and effective treatment avenue for SLE.
Read More
9
We aimed to understand whether probiotics could ease inflammation in autoimmune pancreatitis (AIP) by interfacing with innate immunity. We set up a mouse model of AIP and treated these mice with Lactobacillus gasseri. The treatment appeared to significantly reduce pancreatitis symptoms, potentially via TLR7 signaling in immune cells.
This suggests that Lactobacillus could be a valuable tool in managing AIP, as we observed crucial interactions between the gut microbiota and the body's immune response.
This suggests that Lactobacillus could be a valuable tool in managing AIP, as we observed crucial interactions between the gut microbiota and the body's immune response.
Read More
9
Lactobacillus rhamnosus mitigates gliadin's effects
We investigated the effects of Lactobacillus rhamnosus GG (LGG) in combating inflammation and cellular changes caused by gliadin in celiac disease models. Our study found that pretreating intestinal cells with LGG postbiotics stopped the activation of harmful pathways linked to gliadin, such as mTOR and NF-κβ. Notably, this protective effect was also observed in more complex models using organoids derived from celiac patients. While these findings are promising, further research is necessary to fully understand LGG’s potential benefits in managing celiac disease.
Read More
Most Useful Reviews
9
Onion smell vanished
49 people found this helpful
Awesome! I ordered it due to a persistent onion smell from the lack of beneficial bacteria, and it disappeared entirely even before I finished the box. Many individuals suffer from this issue, but gynecologists often provide no solution. I searched for a remedy and found this one myself.
Read More
10
Complete recovery
21 people found this helpful
I know everyone is different, but after dealing with bacterial vaginosis and trying numerous treatments, I ordered these probiotics. Within two weeks, I was entirely better and haven't experienced a recurrence. I'm committed to taking these as they counteract the cycle of returning issues.
Read More
9
Resolved issues
7 people found this helpful
I highly recommend this product! I really liked it and ordered a second jar. I took it during female dysbiosis and after many years of suffering, everything is now fine. Plus, it has reduced cravings for flour.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 23 Researches
8
- All Researches
9
We examined how probiotics affect immune cells in rheumatoid arthritis (RA) patients. By isolating monocytes from both RA patients and healthy individuals, we created macrophages that were treated with different probiotic bacteria.
Our findings revealed that probiotic treatment shifted macrophages towards a more anti-inflammatory state while reducing markers of inflammation. Notably, probiotics increased levels of beneficial anti-inflammatory substances and decreased harmful inflammatory responses.
This suggests probiotics could play a role in managing RA through their influence on immune cell behavior.
Our findings revealed that probiotic treatment shifted macrophages towards a more anti-inflammatory state while reducing markers of inflammation. Notably, probiotics increased levels of beneficial anti-inflammatory substances and decreased harmful inflammatory responses.
This suggests probiotics could play a role in managing RA through their influence on immune cell behavior.
Read More
9
We explored the potential of Lactobacillus strain LC-STH-13 in treating systemic lupus erythematosus (SLE), a challenging autoimmune disorder. Using female MRL/lpr mice prone to lupus, we found that LC-STH-13 significantly lowered anti-autoantibodies and optimized the balance of immune cells.
Additionally, it reduced kidney inflammation by targeting the TLR9/NF-κB signaling pathway and improved gut health. These results are promising, suggesting that LC-STH-13 could be a safe and effective treatment avenue for SLE.
Additionally, it reduced kidney inflammation by targeting the TLR9/NF-κB signaling pathway and improved gut health. These results are promising, suggesting that LC-STH-13 could be a safe and effective treatment avenue for SLE.
Read More
9
We investigated how diet influences autoimmune diseases, particularly using a ketogenic diet (KD) model. The KD improved conditions in a mouse model of multiple sclerosis by interacting with the gut microbiome.
Notably, lactobacillus variants were linked to reduced immune cell activation. We found that a specific strain, L. murinus, offered protection against autoimmune conditions, demonstrating the potential of lactobacillus combined with diet-dependent compounds to impact immunity positively.
Overall, our findings underscore the importance of dietary factors and gut bacteria in managing autoimmune disorders.
Notably, lactobacillus variants were linked to reduced immune cell activation. We found that a specific strain, L. murinus, offered protection against autoimmune conditions, demonstrating the potential of lactobacillus combined with diet-dependent compounds to impact immunity positively.
Overall, our findings underscore the importance of dietary factors and gut bacteria in managing autoimmune disorders.
Read More
9
We aimed to understand whether probiotics could ease inflammation in autoimmune pancreatitis (AIP) by interfacing with innate immunity. We set up a mouse model of AIP and treated these mice with Lactobacillus gasseri. The treatment appeared to significantly reduce pancreatitis symptoms, potentially via TLR7 signaling in immune cells.
This suggests that Lactobacillus could be a valuable tool in managing AIP, as we observed crucial interactions between the gut microbiota and the body's immune response.
This suggests that Lactobacillus could be a valuable tool in managing AIP, as we observed crucial interactions between the gut microbiota and the body's immune response.
Read More
9
Lactobacillus rhamnosus mitigates gliadin's effects
We investigated the effects of Lactobacillus rhamnosus GG (LGG) in combating inflammation and cellular changes caused by gliadin in celiac disease models. Our study found that pretreating intestinal cells with LGG postbiotics stopped the activation of harmful pathways linked to gliadin, such as mTOR and NF-κβ. Notably, this protective effect was also observed in more complex models using organoids derived from celiac patients. While these findings are promising, further research is necessary to fully understand LGG’s potential benefits in managing celiac disease.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Onion smell vanished
49 people found this helpful
Awesome! I ordered it due to a persistent onion smell from the lack of beneficial bacteria, and it disappeared entirely even before I finished the box. Many individuals suffer from this issue, but gynecologists often provide no solution. I searched for a remedy and found this one myself.
Read More
10
Complete recovery
21 people found this helpful
I know everyone is different, but after dealing with bacterial vaginosis and trying numerous treatments, I ordered these probiotics. Within two weeks, I was entirely better and haven't experienced a recurrence. I'm committed to taking these as they counteract the cycle of returning issues.
Read More
9
Resolved issues
7 people found this helpful
I highly recommend this product! I really liked it and ordered a second jar. I took it during female dysbiosis and after many years of suffering, everything is now fine. Plus, it has reduced cravings for flour.
Read More
9
Decreased inflammation
6 people found this helpful
I learned about this product through recommendations online, as I often experience inflammation in my private parts, especially severe during pregnancy. Initially, I took one capsule daily for about ten days with minimal effect. After pausing for cranberry capsules, I found the effects lacking. Following suggestions to take two capsules daily for half a month, I noticed my inflammation improving significantly. I now maintain by taking one capsule daily.
Read More
9
Normalised flora
3 people found this helpful
I took this probiotic for a month. After two weeks, I was tested for flora and the results were surprising—everything is normal! This hasn’t happened for a long time. Overall, I've ordered more packaging.
Read More
Frequently Asked Questions
9
Normalised flora
3 people found this helpful
I took this probiotic for a month. After two weeks, I was tested for flora and the results were surprising—everything is normal! This hasn’t happened for a long time. Overall, I've ordered more packaging.
9
Onion smell vanished
49 people found this helpful
Awesome! I ordered it due to a persistent onion smell from the lack of beneficial bacteria, and it disappeared entirely even before I finished the box. Many individuals suffer from this issue, but gynecologists often provide no solution. I searched for a remedy and found this one myself.
10
Complete recovery
21 people found this helpful
I know everyone is different, but after dealing with bacterial vaginosis and trying numerous treatments, I ordered these probiotics. Within two weeks, I was entirely better and haven't experienced a recurrence. I'm committed to taking these as they counteract the cycle of returning issues.
9
Resolved issues
7 people found this helpful
I highly recommend this product! I really liked it and ordered a second jar. I took it during female dysbiosis and after many years of suffering, everything is now fine. Plus, it has reduced cravings for flour.
9
Decreased inflammation
6 people found this helpful
I learned about this product through recommendations online, as I often experience inflammation in my private parts, especially severe during pregnancy. Initially, I took one capsule daily for about ten days with minimal effect. After pausing for cranberry capsules, I found the effects lacking. Following suggestions to take two capsules daily for half a month, I noticed my inflammation improving significantly. I now maintain by taking one capsule daily.
9
Vaginitis improvement
1 people found this helpful
Vaginitis has been a recurring issue for me for six months, often requiring treatment. After trying other brands of probiotics unsuccessfully, I decided to give this one a go. After about two weeks (taking two a day), I’ve noticed a significant reduction in discharge and itching. I will continue using it and have already reordered, hoping for complete healing.
9
We explored the potential of Lactobacillus strain LC-STH-13 in treating systemic lupus erythematosus (SLE), a challenging autoimmune disorder. Using female MRL/lpr mice prone to lupus, we found that LC-STH-13 significantly lowered anti-autoantibodies and optimized the balance of immune cells.
Additionally, it reduced kidney inflammation by targeting the TLR9/NF-κB signaling pathway and improved gut health. These results are promising, suggesting that LC-STH-13 could be a safe and effective treatment avenue for SLE.
Additionally, it reduced kidney inflammation by targeting the TLR9/NF-κB signaling pathway and improved gut health. These results are promising, suggesting that LC-STH-13 could be a safe and effective treatment avenue for SLE.
8
Lactobacillus modifies inflammation in lupus
We investigated the effects of Lactobacillus delbrueckii and Lactobacillus rhamnosus on immune responses in newly diagnosed systemic lupus erythematosus patients. By examining blood-derived macrophages, we observed that these probiotics can decrease key inflammatory markers and promote a healthier balance in macrophage populations. Notably, they lowered certain harmful cytokines while increasing beneficial ones in both lupus patients and healthy individuals. Although the probiotics showed promise in inducing an anti-inflammatory profile, their overall effectiveness in managing SLE aspects needs further exploration.
9
We examined how probiotics affect immune cells in rheumatoid arthritis (RA) patients. By isolating monocytes from both RA patients and healthy individuals, we created macrophages that were treated with different probiotic bacteria.
Our findings revealed that probiotic treatment shifted macrophages towards a more anti-inflammatory state while reducing markers of inflammation. Notably, probiotics increased levels of beneficial anti-inflammatory substances and decreased harmful inflammatory responses.
This suggests probiotics could play a role in managing RA through their influence on immune cell behavior.
Our findings revealed that probiotic treatment shifted macrophages towards a more anti-inflammatory state while reducing markers of inflammation. Notably, probiotics increased levels of beneficial anti-inflammatory substances and decreased harmful inflammatory responses.
This suggests probiotics could play a role in managing RA through their influence on immune cell behavior.
References
- Ahmadi P, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Ahmadi-Khorram M, et al. The Impacts of and to Promote In Vitro Anti-Inflammatory Profile of RA-Macrophages. Food Sci Nutr. 2025;13:e70068. 10.1002/fsn3.70068
- Kazemimiraki M, Moazamian E, Mokhtari MJ, Gholamzad M. The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat. Neuromolecular Med. 2025;27:14. 10.1007/s12017-025-08837-1
- Qu H, Fu XX, Han S. C16 peptide and angiopoietin-1 alleviate the side effects of glucocorticoids in a rat multiple sclerosis model. Life Sci. 2025;363:123402. 10.1016/j.lfs.2025.123402
- Liao W, Zhang X, Jia C, Chen W, Cai Y, et al. LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway. Food Funct. 2025;16:475. 10.1039/d4fo03966a
- Alexander M, Upadhyay V, Rock R, Ramirez L, Trepka K, et al. A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity. Cell Rep. 2024;43:114891. 10.1016/j.celrep.2024.114891
- Mirfeizi Z, Mahmoudi M, Jokar MH, Sahebari M, Noori E, et al. Impact of synbiotics on disease activity in systemic lupus erythematosus: Results from a randomized clinical trial. J Food Sci. 2024;89:9835. 10.1111/1750-3841.17460
- Gangaiah D, Gu M, Zaparte A, Will O, Dolan LC, et al. Effects of Limosilactobacillus reuteri strains PTA-126787 and PTA-126788 on intestinal barrier integrity and immune homeostasis in an alcohol-induced leaky gut model. Sci Rep. 2024;14:19584. 10.1038/s41598-024-70549-6
- Straus Farber R, Walker EL, Diallo F, Onomichi K, Riley C, et al. A randomized cross-over trial of prebiotics and probiotics in multiple sclerosis: Trial feasibility, supplement tolerability and symptom abatement. Mult Scler Relat Disord. 2024;89:105762. 10.1016/j.msard.2024.105762
- Sprenger-Svačina A, Klein I, Svačina MKR, Bobylev I, Kohle F, et al. Antibiotics-Induced Intestinal Immunomodulation Attenuates Experimental Autoimmune Neuritis (EAN). J Neuroimmune Pharmacol. 2024;19:26. 10.1007/s11481-024-10119-9
- Ito S, Higashiyama M, Nishimura H, Tomioka A, Tanemoto R, et al. The Role of Gut Microbiota and Innate Immune Response in an Autoimmune Pancreatitis Model. Pancreas. 2024;53:e617. 10.1097/MPA.0000000000002339
- Javanmardi Z, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Shapouri-Moghaddam A, et al. Tolerogenic probiotics Lactobacillus delbrueckii and Lactobacillus rhamnosus promote anti-inflammatory profile of macrophages-derived monocytes of newly diagnosed patients with systemic lupus erythematosus. Cell Biochem Funct. 2024;42:e3981. 10.1002/cbf.3981
- Vahidi Z, Saghi E, Mahmoudi M, RezaieYazdi Z, Esmaeili SA, et al. Lactobacillus rhamnosus and Lactobacillus delbrueckii Ameliorate the Expression of miR-125a and miR-146a in Systemic Lupus Erythematosus Patients. Appl Biochem Biotechnol. 2024;196:6330. 10.1007/s12010-023-04827-w
- Hoseinzadeh A, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Tavakol Afshari J, et al. A new generation of mesenchymal stromal/stem cells differentially trained by immunoregulatory probiotics in a lupus microenvironment. Stem Cell Res Ther. 2023;14:358. 10.1186/s13287-023-03578-z
- Tripathy A, Swain N, Padhan P, Raghav SK, Gupta B. Lactobacillus rhamnosus reduces CD8T cell mediated inflammation in patients with rheumatoid arthritis. Immunobiology. 2023;228:152415. 10.1016/j.imbio.2023.152415
- Furone F, Bellomo C, Carpinelli M, Nicoletti M, Hewa-Munasinghege FN, et al. The protective role of GG postbiotic on the alteration of autophagy and inflammation pathways induced by gliadin in intestinal models. Front Med (Lausanne). 2023;10:1085578. 10.3389/fmed.2023.1085578
- Lin H, Lin J, Pan T, Li T, Jiang H, et al. Polymeric immunoglobulin receptor deficiency exacerbates autoimmune hepatitis by inducing intestinal dysbiosis and barrier dysfunction. Cell Death Dis. 2023;14:68. 10.1038/s41419-023-05589-3
- Samani SA, Moloudi MR, Ramezanzadeh R, Abdi M, Nikkhoo B, et al. Oral Administration of Probiotic to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice. Basic Clin Neurosci. 2022;13:35. 10.32598/bcn.2021.1955.1
- Monzani R, Gagliardi M, Clemente N, Saverio V, Pańczyszyn E, et al. The Gut-Ex-Vivo System (GEVS) Is a Dynamic and Versatile Tool for the Study of DNBS-Induced IBD in BALB/C and C57BL/6 Mice, Highlighting the Protective Role of Probiotics. Biology (Basel). 2022;11. 10.3390/biology11111574
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. 10.1016/j.jaci.2021.03.025
- Liu Y, Hoang TK, Taylor CM, Park ES, Freeborn J, et al. and differentially affect gut microbes and metabolites in mice with Treg deficiency. Am J Physiol Gastrointest Liver Physiol. 2021;320:G969. 10.1152/ajpgi.00072.2021
- Fan Z, Yang B, Ross RP, Stanton C, Zhao J, et al. The prophylactic effects of different Lactobacilli on collagen-induced arthritis in rats. Food Funct. 2020;11:3681. 10.1039/c9fo02556a
- Khorasani S, Mahmoudi M, Kalantari MR, Lavi Arab F, Esmaeili SA, et al. Amelioration of regulatory T cells by Lactobacillus delbrueckii and Lactobacillus rhamnosus in pristane-induced lupus mice model. J Cell Physiol. 2019;234:9778. 10.1002/jcp.27663
- Mardani F, Mahmoudi M, Esmaeili SA, Khorasani S, Tabasi N, et al. In vivo study: Th1-Th17 reduction in pristane-induced systemic lupus erythematosus mice after treatment with tolerogenic Lactobacillus probiotics. J Cell Physiol. 2018;234:642. 10.1002/jcp.26819
Data last updated:
